Exploring the genetic, environmental, and clinical aspects of male infertility as a global health challenge affecting millions worldwide.
Male factor involvement in infertility cases
Klinefelter syndrome in non-obstructive azoospermia
AZF microdeletions in non-obstructive azoospermia
Children conceived via ART in developed countries
Deep within our cells lies an intricate genetic blueprint that guides the miraculous process of sperm production.
Present in approximately 14% of men with non-obstructive azoospermia, this condition (47,XXY) represents the most common genetic cause of male infertility 1 .
Found in 10% of patients with non-obstructive azoospermia and 5% with severe oligozoospermia, these deletions can completely halt sperm production 1 .
Our modern world exposes men to an array of environmental pollutants, with trace elements in seminal plasma emerging as key biomarkers.
| Element | Found in Asthenozoospermia | DNA Fragmentation Correlation | Biological Role |
|---|---|---|---|
| Magnesium | Significantly higher | Positive correlation | Muscle function, energy metabolism |
| Zinc | Significantly higher | Positive correlation | Antioxidant protection, genetic stability |
| Cadmium | Significantly higher | Positive correlation | Toxic element, induces oxidative stress |
Examining the impact of different cryoprotectants on sperm quality, DNA fragmentation, and apoptotic markers.
30 semen samples divided into fertile and infertile groups
Three different media: egg-yolk/glycerol, sucrose/glycerol, glycerol alone
One month at -196°C followed by comprehensive quality assessment
Sophisticated laboratory tools and reagents enabling breakthroughs in understanding sperm function and genetic integrity.
Computer-assisted sperm analysis for precise motility tracking
Sperm Chromatin Structure Assay for DNA fragmentation
Trace element detection in seminal plasma
Isolating high-quality sperm with minimal DNA damage
Precise pore size filtration for sperm selection
Viability assessment and morphological analysis
Male infertility serves as a sentinel for broader health issues, with implications extending far beyond reproductive capacity.
We pinpointed a simple way to restart immotile sperm by adding a cAMP analog. It's an encouraging step toward practical options for some forms of male infertility.