Research Articles
Beyond the Exome: Evaluating RNA-seq as a Complementary Tool to WES for Diagnostic Confirmation in Clinical Genomics
This article provides a comprehensive evaluation of RNA sequencing (RNA-seq) and Whole Exome Sequencing (WES) for diagnostic confirmation in genetic disorders and oncology.
From Sequence to Significance: A Comprehensive Guide to Functional Validation of Genetic Variants
The rapid expansion of next-generation sequencing has generated a deluge of genetic variants of uncertain significance (VUS), creating a critical bottleneck in research and clinical diagnostics.
Advancing Breeding Programs: A Comprehensive Guide to Genomic Prediction Models
This article provides a comprehensive overview of the latest advancements in genomic prediction (GP) models and their transformative impact on modern breeding programs.
Alternative Splicing and Protein Diversity: From Molecular Mechanisms to Therapeutic Applications
This article provides a comprehensive overview of the mechanisms by which alternative splicing generates proteomic diversity, a process crucial for normal development and cellular homeostasis.
Beyond DNA to Protein: The Central Dogma's Evolving Role in Modern Biology and Drug Development
This article provides a comprehensive exploration of the Central Dogma of Molecular Biology, tracing its evolution from a foundational principle to a dynamic framework for understanding gene regulation and its...
Autosomal Dominant vs Recessive Inheritance: Molecular Mechanisms, Clinical Applications, and Implications for Drug Development
This article provides a comprehensive analysis of autosomal dominant and recessive inheritance patterns for researchers and drug development professionals.
The Complete Guide to Whole Exome Sequencing Data Analysis: From Raw Data to Clinical Insights
This comprehensive guide provides researchers, scientists, and drug development professionals with a complete framework for whole exome sequencing (WES) data analysis.
Decoding NBS Domain Interactions: From Structural Dynamics to Therapeutic Discovery
This article provides a comprehensive overview of protein-ligand interaction studies for Nucleotide-Binding Site (NBS) domains, crucial modules in proteins involved in immunity, signaling, and disease.
Harmonizing Genomic Medicine: Strategies to Resolve Interlaboratory Differences in Variant Interpretation
Inconsistent classification of genetic variants across clinical laboratories presents a significant challenge in genomic medicine, with reported discordance rates of 10-40%.
Integrating Heterogeneous Biological Databases: Strategies for Next-Generation Gene Discovery
This article provides a comprehensive guide for researchers and drug development professionals on integrating heterogeneous biological databases to accelerate gene discovery.