Research Articles
Bayesian Alphabet in Genetics: Demystifying BayesA, BayesB, and BayesC for Major and Minor QTL Mapping
This article provides a comprehensive guide for researchers, scientists, and drug development professionals on applying Bayesian alphabet methods—specifically BayesA, BayesB, and BayesC—for mapping both major and minor quantitative trait loci...
BayesA Prior Specification and Parameter Tuning: A Practical Guide for Genomic Prediction and Biomarker Discovery
This article provides a comprehensive guide to BayesA prior specification and hyperparameter tuning, tailored for researchers, scientists, and drug development professionals working with genomic prediction, biomarker identification, and complex trait...
BayesA Genomic Prediction: A Beginner's Guide for Biomedical Researchers
This article provides a comprehensive, step-by-step guide to implementing the BayesA methodology for genomic prediction, tailored for researchers and drug development professionals.
BayesA vs BayesB vs BayesC: A Comprehensive Guide to Genomic Selection Priors for Biomedical Research
This article provides a comprehensive, practical guide to BayesA, BayesB, and BayesC prior distributions for researchers and drug development professionals in the biomedical field.
False Discovery Rates in Differential Expression Analysis: A Practical Guide for Biomarker and Drug Target Validation
This article provides a comprehensive guide to understanding, controlling, and validating False Discovery Rates (FDR) in differential expression analysis for genomics and transcriptomics studies.
VUS Discordance in Genomic Medicine: A Critical Analysis of Inter-Laboratory Classification Concordance and Its Impact on Clinical Decision-Making
This article provides a comprehensive analysis of Variants of Uncertain Significance (VUS) classification concordance across clinical laboratories, a critical challenge in precision medicine.
Optimizing Agrobacterium-Mediated VIGS for Plant Gene Function Studies: A Comprehensive Guide
This article provides a comprehensive guide for researchers utilizing Agrobacterium-mediated Virus-Induced Gene Silencing (VIGS) via cotyledon node infection, a key technique for rapid functional genomics in plants.
Benchmarking Gene Prioritization: An AUC Comparison Guide for Researchers and Drug Developers
This article provides a comprehensive analysis of Area Under the Curve (AUC) metrics for evaluating gene prioritization tools in biomedical research.
APY Algorithm for Large-Scale GBLUP: Efficient Genomic Prediction for Big Data in Biomedical Research
This article provides a comprehensive guide to the Algorithm for Proven and Young (APY) animals for implementing large-scale Genomic Best Linear Unbiased Prediction (GBLUP).
Revolutionizing Drug Discovery: How AI and Neural Backbone Sampling (NBS) Predict Protein-Ligand Interactions
This article provides a comprehensive analysis of AI-driven Neural Backbone Sampling (NBS) for predicting protein-ligand interactions, a critical frontier in computational drug discovery.